Oncolytic Adenovirus Coding for TNFa and IL2 (TILT-123) With Pembrolizumab or Pembrolizumab (Phase 1a) and Pegylated Liposomal Doxorubicin (Phase 1b) as Treatment for Ovarian Cancer. - Join Clinical Trial NCTNCT05271318
How to Join This Clinical Trial - NCTNCT05271318
Learn how to participate in this PHASE1, PHASE2 trial studying an investigational therapy for Platinum-refractory Ovarian Carcinoma, Platinum-resistant Ovarian Cancer, Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Platinum-Refractory Fallopian Tube Carcinoma, Platinum-Refractory Primary Peritoneal Carcinoma, Platinum-Sensitive Ovarian Cancer in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin, Platinum-Sensitive Fallopian Tube Carcinoma in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin, Platinum-Sensitive Primary Peritoneal Carcinoma in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin. This study is currently enrolling participants.
Am I Eligible for This Clinical Trial?
This clinical research study is looking for participants with Platinum-refractory Ovarian Carcinoma, Platinum-resistant Ovarian Cancer, Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Platinum-Refractory Fallopian Tube Carcinoma, Platinum-Refractory Primary Peritoneal Carcinoma, Platinum-Sensitive Ovarian Cancer in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin, Platinum-Sensitive Fallopian Tube Carcinoma in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin, Platinum-Sensitive Primary Peritoneal Carcinoma in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin. Eligibility requirements include specific age ranges, health status, and medical history. Contact the study team to learn if you qualify.
- Condition Being Studied
 - Platinum-refractory Ovarian Carcinoma, Platinum-resistant Ovarian Cancer, Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Platinum-Refractory Fallopian Tube Carcinoma, Platinum-Refractory Primary Peritoneal Carcinoma, Platinum-Sensitive Ovarian Cancer in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin, Platinum-Sensitive Fallopian Tube Carcinoma in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin, Platinum-Sensitive Primary Peritoneal Carcinoma in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin
 - Treatment Being Tested
 - Investigational treatment
 - Study Phase
 - PHASE1, PHASE2 - Safety and effectiveness study
 - Enrollment Status
 - Currently enrolling participants
 - Study Identifier
 - NCTNCT05271318 - ClinicalTrials.gov Identifier
 - Sponsored By
 - Study sponsor
 
What to Expect as a Participant
Participating in this clinical trial involves:
- Initial screening to determine eligibility
 - Regular study visits and health assessments
 - Receiving the study treatment or placebo
 - Medical monitoring and follow-up care
 - Contributing to medical research that may help others
 - Potential access to new treatments before they're widely available
 
Clinical Trial Benefits and Compensation
Participants in this clinical research study may receive:
- Close medical monitoring by healthcare professionals
 - Access to potential new treatments
 - Compensation for time and travel (varies by study)
 - No-cost study-related medical care
 - The opportunity to help advance medical knowledge
 
Where Is This Clinical Trial Located?
This study is enrolling participants at 3 locations. Find a study site near you:
Clinical Research Site
Rochester, Minnesota 55905 - United States
Status: RECRUITING
Clinical Research Site
New York, New York 10075 - United States
Status: RECRUITING
Clinical Research Site
Helsinki,  00180 - Finland
Status: ACTIVE_NOT_RECRUITING
How to Enroll in This Study
To learn more about participating in this PHASE1, PHASE2 clinical trial for Platinum-refractory Ovarian Carcinoma, Platinum-resistant Ovarian Cancer, Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Platinum-Refractory Fallopian Tube Carcinoma, Platinum-Refractory Primary Peritoneal Carcinoma, Platinum-Sensitive Ovarian Cancer in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin, Platinum-Sensitive Fallopian Tube Carcinoma in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin, Platinum-Sensitive Primary Peritoneal Carcinoma in Which the Participant Has Allergy or Severe Intolerance to Carboplatin and/or Cisplatin:
- Review the eligibility criteria with your healthcare provider
 - Contact the study team for a pre-screening interview
 - Schedule an in-person screening visit if eligible
 - Review and sign the informed consent form
 - Begin participation in the clinical trial
 
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